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Biophysics Journal Club
The Emergence of Eukaryotes as an Evolutionary Algorithmic Phase Transition
John Bechhoefer, 間眅埶AV Physics
Location: P8445.2
Thursday, 03 July 2025 12:30PM PDT
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Synopsis
For a billion years, life was simple, consisting of bacteria and archaea. Then, about 2.6 billion years ago, something happened that led to the more complex eukaryotic form of life, with its separated nucleus and organelles. Many people have wondered how this transition happened; Muro et al. instead ask why. Their answer is that evolution in prokaryotes led to more and more complex forms that required more and more extensive evolutionary searches for new proteins. At some point, a second-order phase transition in evolutionary strategy adopting the modularity of eukaryotes and of multicellular organisms allowed for faster evolution. We will examine their argument.